FoundMyFitness

de Rhonda Patrick, Ph.D.

A podcast about health, science, nutrition, aging, and fitness.

Episodios

#069 COVID Vaccine Myths, Questions, and Rumors with Rhonda Patrick and Roger Seheult

por Rhonda Patrick, Ph.D.

In this nearly 2.5-hour episode, Dr. Rhonda Patrick and Dr. Roger Seheult and Kyle Allred of MedCram make a thoughtful, merit-based, and truly comprehensive discussion of COVID-19 vaccination.

In addition to being a co-founder of MedCram Medical Lectures, Dr. Roger Seheult is, as you will find out in the conversation, a boots on the ground, critical care pulmonologist.

For Dr. Seheult, COVID-19 is not just theory. He sees real sick people and for that reason brings a very special context to this conversation. Furthermore, Dr. Seheult is also an academic and educator. He is an Associate Clinical Professor at the University of California, Riverside School of Medicine and an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple-board certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine and Sleep Medicine through the American Board of Internal Medicine.

In this episode, we discuss:

  • Vaccination in the young and healthy
  • Long-haul COVID
  • Spike protein cytotoxicity
  • COVID-19 Vaccine Adverse Event Reporting System (VAERS)
  • Antibody-dependent enhancement
  • Fertility and biodistribution data
  • Whether or not mRNA vaccines alter human DNA
  • Current ivermectin evidence
  • Delta-variant and breakthrough infections
  • Viral evolution (virulence vs. immune escape)
  • T-cell immunity vs. antibody immunity

Watch the annotated video:
https://www.youtube.com/watch?v=pp-nPZETLTo

Subscribe to MedCram on Apple Podcasts:
https://podcasts.apple.com/us/podcast/medcram/id1564795918

Subscribe to MedCram on YouTube:
https://www.youtube.com/channel/UCG-iSMVtWbbwDDXgXXypARQ

#068 Dr. Bill Harris on omega-3 fatty acids, cardiovascular health, and inflammation

por Rhonda Patrick, Ph.D.

Dr. William ("Bill") Harris is one of the world's preeminent experts in the field of omega-3 fatty acid research. His work has focused on the roles that fatty acids in play in cardiovascular and neurocognitive health.

The author of more than 300 scientific papers on fatty acids and health, Dr. Harris is a professor in the Department of Medicine in the Sanford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute.

In this episode, Dr. Harris and I discuss…

  • How early studies on dietary fats and cholesterol levels spawned the field of omega-3 research.
  • How standards of "normal" bleeding time may be abnormally high in Western countries, leading to some misconception on the effects of omega-3.
  • How different types of omega-3s, such as alpha-linolenic acid, share structural similarities with marine omega-3s but not the same cardioprotective effects.
  • How genetic engineering of plants may yield abundant, sustainable omega-3s in the future.
  • What the omega-3 index test is, how it was created, and how it reveals individual variations in how much omega-3 we may need.
  • How red blood cell concentration of omega-3s better reflect long-term omega-3 status.
  • How the omega-3 index may predict life expectancy.
  • How genetic variants influence omega-3 dietary needs.
  • How metabolites of omega-3 metabolism reduce and resolve inflammation.
  • How people with high omega-3 concentrations were half as likely to die from COVID-19.
  • How the omega-3 DHA may help keep the SARS-CoV-2 spike protein from entering cells.
  • How concerns over the omega-6/omega-3 ratio may be unfounded, and it really may boil down to just how much omega-3 you're taking in.

Looking for more? 

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#067 Dr. Ashley Mason on Drug-free Approaches for Treating Depression, Insomnia, and Overeating

por Rhonda Patrick, Ph.D.

Dr. Ashley Mason is a clinical psychologist and director of the Sleep, Eating, and Affect Laboratory at the Osher Center for Integrative Medicine at UCSF. Her research centers on nonpharmacological approaches for treating depression, insomnia, and overeating.

In this episode, you’ll hear Rhonda and Ashley discuss:

  • How whole-body hyperthermia (WBH) and sauna use differ. 
  • How people with depression have thermoregulatory dysfunction – but sauna use may correct it.
  • How WBH and sauna use may reduce symptoms of depression.
  • How heating the body slowly may improve heat tolerance and increase WBH effectiveness. 
  • How sauna use may benefit people with depression and cardiovascular disease – which often coincide. 
  • How Dr. Mason and I are collaborating on a new research project to measure biomarkers associated with depression and WBH.
  • How sauna bathing and similar practices often provide opportunities for people to connect socially. 
  • How insomnia differs from being a "night owl."
  • How insomnia often arises from major changes in a person's life. 
  • How cognitive behavioral therapy, sleep hygiene, stimulus control, and sleep restriction can help treat insomnia without drugs.  
  • and so much more!

Looking for more? 

Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#066 Dr. Mark Mattson on the Benefits of Stress, Metabolic Switching, Fasting, and Hormesis

por Rhonda Patrick, Ph.D.

Dr. Mark Mattson

Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature.

Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting.

In this episode, Dr. Mattson and I discuss...

  • How hormetic stressors drive adaptation and prevent physiological complacency.
  • How intermittent fasting improves health by promoting metabolic switching.
  • How daily time-restricted eating and 5:2 weekly fasting compare.
  • How a ketogenic diet and intermittent fasting differ in terms of brain effects.
  • How exercising while intermittent fasting exerts additive effects.
  • How plant-based bioactive compounds induce hormetic stress.
  • How severe caloric restriction may harm the body and compromise muscle mass.
  • The differing contexts of intermittent fasting: young vs. old and in men vs. in women.
  • How the effects of cortisol differ during a fast versus chronic uncontrollable stress.
  • How the effects of fasting-mimetics like resveratrol and spermidine compare with actual fasting, and;
  • How ketone supplementation may improve brain health

Show notes coming soon!

Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly:
https://www.foundmyfitness.com/newsletter


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#065 Dr. Satchin Panda on Circadian Insights into Exercise Timing, Melatonin Biology, and Peak Cognition

por Rhonda Patrick, Ph.D.

Dr. Satchin Panda

Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. 

Dr. Panda’s work focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches. He is an expert on circadian rhythms and a pioneer in the field of time-restricted eating. A priority for Dr. Panda when designing his studies is to identify strategies that positively impact public health.

In this episode, Dr. Panda and I discuss...

  • 00:05:31 - How circadian rhythms influence human health.
  • 00:12:30 - How seeking bright light in the morning and avoiding it in the evening can help us sleep better.
  • 00:20:40 - How the ability of supplemental melatonin to counteract evening bright light exposure varies.
  • 00:26:16 - How understanding the relationship between melatonin and insulin secretion might help us decide when to eat.
  • 00:33:15 - How shift work, jet lag, and modern lifestyles contribute to altered circadian rhythms and metabolic dysfunction.
  • 00:45:10 - How naps might aid with afternoon sleepiness and sleep loss.
  • 00:47:05 - How we can tailor our indoor lighting environment to promote healthy circadian rhythms.
  • 00:51:20 - How time-restricted eating (eating within a narrow time range) can be beneficial.
  • 01:02:13 - How Dr. Panda’s ongoing study uses a smartphone app to track when people eat.
  • 01:03:41 - How most people are unaware of their eating patterns.
  • 01:07:58 - How Dr. Panda incorporates his research findings into his own life.
  • 01:16:21 - How our circadian rhythms dictate when we should exercise – and how caffeine provides a workaround.

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/satchin-panda-3

Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#064 Dr. Michael Snyder on Continuous Glucose Monitoring and Deep Profiling for Personalized Medicine

por Rhonda Patrick, Ph.D.

Michael Snyder

Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics.

In this episode, you'll discover:

  • 00:12:51 - Continuous glucose monitors
  • 00:31:04 - Lyme disease
  • 00:34:00 - Predicting illness with smartwatches
  • 00:39:14 - Heart rate variability
  • 00:40:41 - Exposome and airborne pollutants
  • 00:51:04 - Discovering Ageotypes
  • 00:58:05 - Exercise benefits
  • 01:03:11 - Michael Snyder's lifestyle habits

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/michael-snyder

Join over 300,000 people and get the latest distilled information on personalized medicine straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Dr. Michael Snyder on Continuous Glucose Monitoring and Deep Profiling for Personalized Medicine

por Rhonda Patrick, Ph.D.

Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics.

Chapters:

  • 00:12:51 - Continuous glucose monitors
  • 00:31:04 - Lyme disease
  • 00:34:00 - Predicting illness with smartwatches
  • 00:39:14 - Heart rate variability
  • 00:40:41 - Exposome and airborne pollutants
  • 00:51:04 - Discovering Ageotypes
  • 00:58:05 - Exercise benefits
  • 01:03:11 - Michael Snyder's lifestyle habits

Get this show's notes, timeline, and transcript:
https://www.foundmyfitness.com/episodes/michael-snyder

Dr. Snyder's faculty bio page:
https://profiles.med.stanford.edu/michael-snyder

Dr. Snyder on Twitter:
https://twitter.com/SnyderShot

COVID-19 Tracking Study:
https://innovations.stanford.edu/wearables

Free metabolism SNP report for consumer genetic data:
https://www.foundmyfitness.com/genetics/metabolism

Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy

por Rhonda Patrick, Ph.D.

Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity.
What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic.

In other words, when it comes to COVID-19 for Dr. Seheult... it's personal. He has worked tirelessly not just to help people find their way back to wellness as a critical care provider, but he broadcasts the insights he has gained realtime to the 1 million subscribers listening to his medical lecture platform he co-founded with physician assistant Kyle Allred.

Listen to this episode to hear Dr. Seheult's thoughts on:

  • 00:06:20 - How MedCram Videos got started and the future of medical education from Dr. Seheult's standpoint.
  • 00:09:37 - What to do when life is on the line and the usual hierarchy of evidence doesn't exist, as in early emergency COVID-19 treatment.
  • 00:12:46 - The crucial differences in treating early vs. late-stage COVID-19 illness.
  • 00:14:40 - How doctors would've treated COVID-19 one-hundred years ago.
  • 00:18:13 - How increasing ventilation may powerfully impact COVID-19 disease transmission and why airplanes have surprisingly little disease transmission.
  • 00:20:28 - How masks are virtually universally beneficial in the pandemic regardless of type.
  • 00:21:32 - Vitamin D and COVID-19
  • 00:22:22 - How the steroid chemical structure of vitamin D confers qualities on vitamin D that other vitamins ("vital amines") do not possess, such as membrane permeability that provides access to the nucleus and broad gene regulatory effects mediated by a specialized vitamin D receptor element.
  • 00:23:24 - How calcium homeostasis, which was the early and exclusive focus for scientists and doctors that were trying to determine the ideal vitamin D levels, may have caused the RDA to be set too low since we now know vitamin D regulates around 5% of the protein-encoding genome and have much broader effects.
  • 00:24:23 - How the hormonal role of vitamin D confers on it properties more similar to other hormones like testosterone and cortisol rather than those of ordinary vitamins.
  • 00:26:21 - The surprising level of overlap between COVID-19 positivity and groups most affected by vitamin D deficiency and the surprise finding of how less than 50 ng/mL blood levels of vitamin D associated with greater likelihood of SARS-CoV-2 positivity in the hospital.
  • 00:30:27 - How scientists are able to interrogate the effects of low vitamin D levels through genetic research, a type of study known as mendellian randomization.
  • 00:34:20 - The gene regulatory effects of vitamin D and the implications for the scale of its biological impact.
  • 00:35:49 - How Vitamin D's ACE2/renin-angiontensin-promoting effects may be mechanistically involved in the effects observed in vitamin D COVID-19 studies.
  • 00:42:00 - Why ameliorating vitamin D deficiency in one large monthly bolus might be less effective than daily or weekly doses.
  • 00:43:23 - How a prescription-only form of vitamin D known as Calcifediol might have an advantage in acute care for COVID-19.
  • 00:47:06 - Why skin synthesis of vitamin D from UV B radiation can be extraordinarily unreliable when compared to supplementation.
  • 00:53:43 - What the safest dose range for vitamin D is that should also address deficiency in most populations.
  • 01:06:15 - The beneficial circadian effect of early morning sunlight.
  • 01:07:38 - How sleep deprivation is meaningfully implicated in profound and immediate impairment of viral immunity.
  • 01:12:08 - Dr. Seheult's suggestions for how to achieve the highest quality of sleep.
  • 01:19:18 - How a century old sanitarium technique used during the Spanish flu era massively boosts interferon by up to ten-times using heat exposure.
  • 01:22:38 - How genetic and antibody-induced failures of the interferon system underpin up to 14% of all severe cases of COVID-19 and why interferon is so vitally important for viral response.
  • 01:26:43 - Why treating the symptoms of fever during the spanish flu turned out to not be a good idea, immunologically speaking.
  • 01:31:58 - Dr. Seheult's on-going research into using hot hydrotherapy as a viral immunity booster.
  • 01:47:00 - COVID-19 Vaccines

Here's some web pages related to the show and this episode that we think you should check out...

You can access the show's notes, timeline, and transcript here.

Try out a preview of our premium podcast The Aliquot Preview.

Learn about FoundMyFitness premium membership and our twice-per-month science news updates we send out just to members called the Science Digest.

#063 Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy

por Rhonda Patrick, Ph.D.

Dr. Roger Seheult
Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity.
 
What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic.

In this episode, you'll discover:

  • 00:06:20 - How MedCram Videos got started and the future of medical education from Dr. Seheult's standpoint.
  • 00:09:37 - What to do when life is on the line and the usual hierarchy of evidence doesn't exist, as in early emergency COVID-19 treatment.
  • 00:12:46 - The crucial differences in treating early vs. late-stage COVID-19 illness.
  • 00:14:40 - How doctors would've treated COVID-19 one-hundred years ago.
  • 00:18:13 - How increasing ventilation may powerfully impact COVID-19 disease transmission and why airplanes have surprisingly little disease transmission.
  • 00:20:28 - How masks are virtually universally beneficial in the pandemic regardless of type.
  • 00:21:32 - Vitamin D and COVID-19
  • 00:22:22 - How the steroid chemical structure of vitamin D confers qualities on vitamin D that other vitamins ("vital amines") do not possess, such as membrane permeability that provides access to the nucleus and broad gene regulatory effects mediated by a specialized vitamin D receptor element.
  • 00:23:24 - How calcium homeostasis, which was the early and exclusive focus for scientists and doctors that were trying to determine the ideal vitamin D levels, may have caused the RDA to be set too low since we now know vitamin D regulates around 5% of the protein-encoding genome and have much broader effects.
  • 00:24:23 - How the hormonal role of vitamin D confers on it properties more similar to other hormones like testosterone and cortisol rather than those of ordinary vitamins.
  • 00:26:21 - The surprising level of overlap between COVID-19 positivity and groups most affected by vitamin D deficiency and the surprise finding of how less than 50 ng/mL blood levels of vitamin D associated with greater likelihood of SARS-CoV-2 positivity in the hospital.
  • 00:30:27 - How scientists are able to interrogate the effects of low vitamin D levels through genetic research, a type of study known as mendellian randomization.
  • 00:34:20 - The gene regulatory effects of vitamin D and the implications for the scale of its biological impact.
  • 00:35:49 - How Vitamin D's ACE2/renin-angiontensin-promoting effects may be mechanistically involved in the effects observed in vitamin D COVID-19 studies.
  • 00:42:00 - Why ameliorating vitamin D deficiency in one large monthly bolus might be less effective than daily or weekly doses.
  • 00:43:23 - How a prescription-only form of vitamin D known as Calcifediol might have an advantage in acute care for COVID-19.
  • 00:47:06 - Why skin synthesis of vitamin D from UV B radiation can be extraordinarily unreliable when compared to supplementation.
  • 00:53:43 - What the safest dose range for vitamin D is that should also address deficiency in most populations.
  • 01:06:15 - The beneficial circadian effect of early morning sunlight.
  • 01:07:38 - How sleep deprivation is meaningfully implicated in profound and immediate impairment of viral immunity.
  • 01:12:08 - Dr. Seheult's suggestions for how to achieve the highest quality of sleep.
  • 01:19:18 - How a century old sanitarium technique used during the Spanish flu era massively boosts interferon by up to ten-times using heat exposure.
  • 01:22:38 - How genetic and antibody-induced failures of the interferon system underpin up to 14% of all severe cases of COVID-19 and why interferon is so vitally important for viral response.
  • 01:26:43 - Why treating the symptoms of fever during the spanish flu turned out to not be a good idea, immunologically speaking.
  • 01:31:58 - Dr. Seheult's on-going research into using hot hydrotherapy as a viral immunity booster.
  • 01:47:00 - COVID-19 Vaccines

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/roger-seheult

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#062 Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

por Rhonda Patrick, Ph.D.

Steve Horvath

Steve Horvath, PhD, is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health

Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/steve-horvath

Join over 300,000 people and get the latest distilled information on aging straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Q&A with Dr. Jed Fahey on Sulforaphane, Moringa and Chemoprotection

por Rhonda Patrick, Ph.D.

In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.

Get the full timeline and show notes.

Listen to learn Dr. Fahey's thoughts on…

  • 00:07:19 - The minimum daily dose of sulforaphane that elicits beneficial health effects
  • 00:12:04 - Why gauging the amount of sulforaphane in foods presents challenges
  • 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods
  • 00:23:38 - How often to consume broccoli sprouts and how long their effects last
  • 00:39:28 - The effects of sulforaphane on glutathione production in the brain
  • 00:43:12 - The effects of sulforaphane on cancer
  • 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends)
  • 01:33:08 - Safety concerns regarding sulforaphane

In this episode, Dr. Fahey mentions the following companies, websites, and supplements:

Extra resources

Learn how to sprout at home safely by downloading the 15-page sprouting guide developed with Dr. Fahey.

Sign-up to participate in the live every-single-month Q&A series by becoming a FoundMyFitness premium member.

#061 Q&A with Dr. Jed Fahey on Sulforaphane, Moringa and Chemoprotection

por Rhonda Patrick, Ph.D.

Dr. Jed Fahey

In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.

 

In this episode, you'll discover:

  • 00:07:19 - The minimum daily dose of sulforaphane that elicits beneficial health effects
  • 00:12:04 - Why gauging the amount of sulforaphane in foods presents challenges
  • 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods
  • 00:23:38 - How often to consume broccoli sprouts and how long their effects last
  • 00:39:28 - The effects of sulforaphane on glutathione production in the brain
  • 00:43:12 - The effects of sulforaphane on cancer
  • 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends)
  • 01:33:08 - Safety concerns regarding sulforaphane

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/jed-fahey-q-a

Join over 300,000 people and get the latest distilled information  straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#060 Dr. Giselle Petzinger on Exercise for Parkinson's Disease

por Rhonda Patrick, Ph.D.

Giselle Petzinger

Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.

Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.

 

In this episode, you'll discover:

  • 00:06:57 - What is Parkinson’s disease?
  • 00:11:57 - How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1
  • 00:14:57 - How other circuits in the brain can compensate for the loss of function of the substantia nigra.
  • 00:18:37 - Prevalence and hereditary risk factors of Parkinson’s disease. 
  • 00:21:25 - How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1 
  • 00:26:57 - How exercise can lower the risk of developing Parkinson’s disease. 1 2 3
  • 00:35:38 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space.
  • 00:47:49 - How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2 
  • 00:58:33 - How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1
  • 01:01:31 - Why exercise may not fully replace the use of medications.
  • 01:09:58 - How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4
  • 01:12:12 - How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/giselle-petzinger

Join over 300,000 people and get the latest distilled information on parkinson's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

 

Dr. Giselle Petzinger on Exercise for Parkinson's Disease

por Rhonda Patrick, Ph.D.

Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California and today’s guest, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.

Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.

In this episode, we discuss...

  • 00:06:57 - What is Parkinson’s disease?
  • 00:11:57 - How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1
  • 00:14:57 - How other circuits in the brain can compensate for the loss of function of the substantia nigra.
  • 00:18:37 - Prevalence and hereditary risk factors of Parkinson’s disease.
  • 00:21:25 - How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1
  • 00:26:57 - How exercise can lower the risk of developing Parkinson’s disease. 1 2 3
  • 00:35:38 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space.
  • 00:47:49 - How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2
  • 00:58:33 - How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1
  • 01:01:31 - Why exercise may not fully replace the use of medications.
  • 01:09:58 - How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4
  • 01:12:12 - How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1

Click here to get this episode's show notes and transcript

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Aliquot #3: Q&A Mashup - Fasting

por Rhonda Patrick, Ph.D.

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This collection of clips covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, purported health benefits, and when and how to break the fast.

Episode Highlights

  • 00:01:36 - Fasting mimicking diet, the ketogenic diet and autoimmune diseases

  • 00:13:42 - Spermidine is a fasting mimetic compound

  • 00:16:51 - Aerobic exercises in a fasting state induces autophagy quicker than in a fed state.

  • 00:25:15 - Intermittent fasting, prolonged fasting and healthspan.
  • 00:28:02 - What we know about the minimal fasting time it takes to induce autophagy and apoptosis.

  • 00:33:35 - Comparing and contrasting a ketogenic diet with prolonged fasting.

  • 00:37:33 - Rhonda compares the rejuvenation effect of time-restricted eating vs prolonged fasting vs fasting mimicking diet.

  • 00:41:16 - Rhonda's thoughts on coffee breaking a fast.

  • 00:52:29 - Supplements and other medications outside of a time-restricted eating window.

  • 01:01:28 - Differences between a fasting-mimicking diet vs a water-only fast.

Learn more about our premium podcast feed The Aliquot by clicking here.

Learn more about premium membership benefits by clicking here.

#059 Aliquot #3: Q&A Mashup - Fasting

por Rhonda Patrick, Ph.D.

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This collection of clips covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, purported health benefits, and when and how to break the fast.

 

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#058 Aliquot #2: Q&A Mashup - Sauna

por Rhonda Patrick, Ph.D.

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

 

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Aliquot #2: Q&A Mashup - Sauna

por Rhonda Patrick, Ph.D.

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This collection of clips covers some of the many health benefits associated with sauna use, including heat shock protein activation, cardiovascular health, muscle mass preservation, and more.

Episode Highlights

  • 00:07:00 - What are the effects of sauna and hot baths on heat shock proteins and the immune system?

  • 00:16:14 - What are your recommendations for infrared sauna temperature and time?

  • 00:24:03 - At what temperature and how long do you need to stay in the sauna to activate heat shock proteins?

  • 00:26:50 - Does sauna use promote excretion of heavy metals such as arsenic?
  • 00:29:12 - Are there ways of mimicking sauna use without regular access to a sauna?

  • 00:33:55 - If compounds such as metformin, resveratrol and vitamin E counteract exercise-induced hormesis, would this be true for other stressors such as the sauna, fasting, broccoli sprouts, polyphenols?

  • 00:37:06 - How does fasting affect human growth hormone and IGF-1 in respect to muscle mass?

  • 00:43:30 - Can saunas be used during fasting to preserve more muscle and increase fat burning?

  • 00:45:50 - Can saunas be used to treat headaches?

Learn more about our premium podcast feed The Aliquot by clicking here.

Learn more about premium membership benefits by clicking here.

Aliquot #1: Q&A Mashup - Pregnancy and child development

por Rhonda Patrick, Ph.D.

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As.

Just for a few examples, it covers...

  • My pre-pregnancy regimen, including diet, exercise, vitamins and sleep
  • Nutrition for babies and toddlers to maximize brain development and growth
  • Extra precautions that I took during my pregnancy
  • And much, much more!

Learn more about our premium podcast feed The Aliquot by clicking here.

Learn more about premium membership benefits by clicking here.

#057 Aliquot #1: Q&A Mashup - Pregnancy and child development

por Rhonda Patrick, Ph.D.

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As.

Just for a few examples, it covers...

  • My pre-pregnancy regimen, including diet, exercise, vitamins and sleep
  • Nutrition for babies and toddlers to maximize brain development and growth
  • Extra precautions that I took during my pregnancy
  • And much, much more!

 

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#056 The Biology of Breast Milk

por Rhonda Patrick, Ph.D.

This episode aims to be the most comprehensive video compendium on the biology of breast milk ever recorded.

In this episode, you'll discover:

  • 00:07:11 - Breast milk composition and production
  • 00:09:59 - Human milk oligosaccharides in breast milk establish the infant gut microbiome
  • 00:15:48 - Omega-3 fatty acids and other components in breast milk boost brain development
  • 00:18:14 - Vitamins and minerals in breast milk
  • 00:22:05 - Breast milk stem cells and multi-organ microchimerism
  • 00:22:54 - Harmful substances transferred to infant via breast milk
  • 00:28:03 - The effects of breastfeeding on the infant's immune system
  • 00:31:17 - Effects on intelligence
  • 00:34:36 - Breastfeeding as a benefit to maternal health

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/breast-milk

Join over 300,000 people and get the latest distilled information on the biology of breast milk straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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The Biology of Breast Milk

por Rhonda Patrick, Ph.D.

This episode aims to be the most comprehensive compendium on the biology of breast milk ever recorded. Looking at the converging clinical and animal evidence of the impact of breast milk paints a complex and beautiful mosaic of developmentally supportive effects that range from allowing the mother to act as a “compensatory” immune system to possibly supporting the development of entire organ systems through the integration of maternal stem cells found in breast milk.

Episode Highlights

  • 00:07:11 - Breast milk composition and production
  • 00:09:59 - Human milk oligosaccharides in breast milk establish the infant gut microbiome
  • 00:15:48 - Omega-3 fatty acids and other components in breast milk boost brain development
  • 00:18:14 - Vitamins and minerals in breast milk
  • 00:22:05 - Breast milk stem cells and multi-organ microchimerism
  • 00:22:54 - Harmful substances transferred to infant via breast milk
  • 00:28:03 - The effects of breastfeeding on the infant's immune system
  • 00:31:17 - Effects on intelligence
  • 00:34:36 - Breastfeeding as a benefit to maternal health

Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.

Breastmilk and breast feeding is now a dedicated Topic section on the website. View that article by clicking here.

Did you enjoy this episode? If you’re interested in learning more about this topic, check out a preview of our very first Aliquot episode: Aliquot #001: Pregnancy & Child Development. It features a compilation of pregnancy and child development-related topics taken from several Q&A episodes over the last couple of years.

#055 COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

por Rhonda Patrick, Ph.D.

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things.

In this episode, you'll discover:

  • 00:04:03 - Data surrounding SARS-CoV-2 duration
  • 00:06:37 - SARS-CoV-2 and potential immunity
  • 00:11:35 - Some of the main factors known to play a role in immune variation
  • 00:12:05 - What role genetics may play in immune function
  • 00:14:27 - How previous viral exposure regulates immunity
  • 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2
  • 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance
  • 00:21:50 - How sleep is a key regulator of immune function
  • 00:23:44 - Microbiome composition and immune function
  • 00:28:31 - The differential effects of exercise intensity and duration on immune regulation
  • 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation
  • 00:47:20 - The effect of sex hormones on immune function
  • 00:48:55 - How biological age age may play a role in immune regulation
  • 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
  • 00:53:15 - ARDS and long-term lung damage

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/covid-19-episode-2

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

por Rhonda Patrick, Ph.D.

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things.

Some of the topics that came up as a result of the questions submitted include:

  • 00:04:03 - Data surrounding SARS-CoV-2 duration
  • 00:06:37 - SARS-CoV-2 and potential immunity
  • 00:11:35 - Some of the main factors known to play a role in immune variation
  • 00:12:05 - What role genetics may play in immune function
  • 00:14:27 - How previous viral exposure regulates immunity
  • 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2
  • 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance
  • 00:21:50 - How sleep is a key regulator of immune function
  • 00:23:44 - Microbiome composition and immune function
  • 00:28:31 - The differential effects of exercise intensity and duration on immune regulation
  • 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation
  • 00:47:20 - The effect of sex hormones on immune function
  • 00:48:55 - How biological age age may play a role in immune regulation
  • 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
  • 00:53:15 - ARDS and long-term lung damage

Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.

This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out.

If you enjoy this content or any of the associated content, I can promise you that not only does the premium membership help bring MORE of it into the world in a broadly accessible format, that membership also comes with some really great benefits just for members. Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line.

#054 Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

por Rhonda Patrick, Ph.D.

In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

In this episode, you'll discover:

  • 00:07:33 - Background on vitamin C
  • 00:17:09 - Bioavailability of vitamin C [including dosing frequency]
  • 00:22:53 - Vitamin C in the context of the common cold
  • 00:28:09 - Vitamin C and lung function
  • 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation]
  • 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity
  • 00:48:44 - Vitamin C and the brain 
  • 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection
  • 00:55:33 - Intravenous Vitamin C and cancer
  • 00:57:40 - Effect of Vitamin C on fertility and reproduction
  • 00:58:36 - Intravenous vitamin C and cardiovascular health
  • 01:00:42 - Vitamin C and inflammation
  • 01:02:38 - Vitamin C’s mechanisms of action 
  • 01:08:34 - Intravenous and Oral vitamin C safety
  • 01:10:20 - Vitamin C intake and kidney stone risk
  • 01:13:57 - Conclusions

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/vitamin-c

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

por Rhonda Patrick, Ph.D.

In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

Episode Timeline (abridged)

  • 00:07:33 - Background on vitamin C
  • 00:17:09 - Bioavailability of vitamin C [including dosing frequency]
  • 00:22:53 - Vitamin C in the context of the common cold
  • 00:28:09 - Vitamin C and lung function
  • 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation]
  • 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity
  • 00:48:44 - Vitamin C and the brain
  • 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection
  • 00:55:33 - Intravenous Vitamin C and cancer
  • 00:57:40 - Effect of Vitamin C on fertility and reproduction
  • 00:58:36 - Intravenous vitamin C and cardiovascular health
  • 01:00:42 - Vitamin C and inflammation
  • 01:02:38 - Vitamin C’s mechanisms of action
  • 01:08:34 - Intravenous and Oral vitamin C safety
  • 01:10:20 - Vitamin C intake and kidney stone risk
  • 01:13:57 - Conclusions

Get the full timeline, show summary, and all references for this episode by clicking here.

View our new 28-page vitamin C overview article with over 190 references by clicking here.

Premium membership: Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line. Click here to learn more about premium membership.

#053 COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

por Rhonda Patrick, Ph.D.

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon. 

In this episode, you'll discover:

  • 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?
  • 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?
  • 00:17:58 - Can you talk about quercetin's role as a zinc ionophore? 
  • 00:20:51 - Is there any indication blood type influences COVID-19 risk?
  • 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?
  • 00:43:45 - Can you discuss whether sauna use might help prevent COVID19?
  • 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19?
  • 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/covid-19-episode-1

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

por Rhonda Patrick, Ph.D.

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon.

Some of the questions we selected from the batch to cover in this episode include:

  • 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?
  • 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?
  • 00:17:58 - Can you talk about quercetin's role as a zinc ionophore?
  • 00:20:51 - Is there any indication blood type influences COVID-19 risk?
  • 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?
  • 00:43:45 - Can you discuss whether sauna use might help prevent COVID19?
  • 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19?
  • 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

To supplement this podcast Q&A, we’ve also made a video, summary, timeline, and references. You can view all of these on the episodes page on my website at foundmyfitness.com/episodes/covid-19-qa-1.

If you enjoy this question & answer format, consider joining my premium membership community! Non-COVID-19 related Q&As happen monthly, you get access to an an exclusive bi-weekly science digest email, and much more more! Click here to learn about premium.

#052 New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

por Rhonda Patrick, Ph.D.

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, you'll discover:

  • 00:08:00 - Omega-3
  • 00:27:23 - Metformin
  • 00:50:05 - Sulforaphane
  • 01:06:57 - Magnesium L-Threonate
  • 01:13:44 - Sauna
  • 01:23:48 - New FMF Membership

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/rhonda-krs-2

Join over 300,000 people and get the latest distilled information on sulforaphane research straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

 

New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

por Rhonda Patrick, Ph.D.

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, we discuss...

  • 00:08:00 - Omega-3
  • 00:27:23 - Metformin
  • 00:50:05 - Sulforaphane
  • 01:06:57 - Magnesium L-Threonate
  • 01:13:44 - Sauna
  • 01:23:48 - New FMF Membership

Learn more about the new premium membership.

Learn more about sauna on our overview page.

Learn more about metformin on our overview page.

Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts:

Is Resveratrol a Longevity Compound?

por Rhonda Patrick, Ph.D.

In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

Learn more about resveratrol at our comprehensive overview

Relevant timepoints...

  • 00:03:39 - Clinical effects of resveratrol in humans
  • 00:04:10 - Effects on cardiovascular health biomarkers in humans
  • 00:06:54 - Reduction of inflammatory biomarkers in humans
  • 00:08:11 - Improved cognition and memory in clinical studies
  • 00:11:23 - Healthspan improvements in animals
  • 00:12:28 - Induction of longevity genes via xenohormesis
  • 00:16:19 - Contradictory effects on exercise-associated benefits
  • 00:20:34 - Various factors that affect resveratrol bioavailability
  • 00:23:09 - Unintentional effects on drug metabolism

Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium.

Click here to sign-up for a three issue trial of the bi-monthly science digest.

#051 Is Resveratrol a Longevity Compound?

por Rhonda Patrick, Ph.D.

Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

In this episode, you’ll discover:

  • 00:03:39 - Clinical effects of resveratrol in humans
  • 00:04:10 - Effects on cardiovascular health biomarkers in humans
  • 00:06:54 - Reduction of inflammatory biomarkers in humans
  • 00:08:11 - Improved cognition and memory in clinical studies
  • 00:11:23 - Healthspan improvements in animals
  • 00:12:28 - Induction of longevity genes via xenohormesis
  • 00:16:19 - Contradictory effects on exercise-associated benefits
  • 00:20:34 - Various factors that affect resveratrol bioavailability
  • 00:23:09 - Unintentional effects on drug metabolism

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/resveratrol-longevity

Join over 300,000 people and get the latest distilled information on resveratrol straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#050 NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide

por Rhonda Patrick, Ph.D.

In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts.

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/nad-nr-nmn

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

por Rhonda Patrick, Ph.D.

In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts.

Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

#049 Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

por Rhonda Patrick, Ph.D.

David A. Sinclair

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.

Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

In this episode, you'll discover:

  • 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity.
  • 00:21:47 - How NAD+ levels and sirtuin activities decrease with age, and how animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger.
  • 00:23:03 - How resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period.
  • 00:27:36 - We also discuss Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, and how they may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock.
  • 00:31:54 - How the signal that resets the epigenetic clock in mice involves the Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type.
  • 00:46:48 - How resveratrol is a xenohormetic compound and is produced when grape plants are stressed either in response to fungus or lack of water.
  • 00:55:35 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved cognitive function, improved cerebrospinal fluid amyloid beta levels, lowered markers of activated microglia, and more.
  • 00:58:03 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease.
  • 01:06:19 - How older mice that were given nicotinamide mononucleotide experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose had improved mitochondrial function and enhanced physical performance.
  • 01:01:22 - How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits.
  • And so much more!

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/david-sinclair

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